Gout Long Term can cause Neurodegenerative Disease, Effects, Smaller Brain Volume and Stroke.

Gout is being unstated as a major culprit of brain damage since most websites dont state how it can and does cause major damage to soft tissues. Found some medical literature stating how important it is to keep uric acid and gout at bay. If gout has a lacerating/cutting effect on surrounding tissue then this would mean that sodium urate and uric acid can have damaging effects on brain tissue including the blood brain barrier.


https://www.nature.com/articles/s41467-023-38602-6#:~:text=Gout%20is%20causally%20related%20to%20smaller%20brain%20volume%2C%20a%20proxy,dementia%20incidence%20was%20non%2Dlinear.


https://www.nature.com/articles/s41598-021-86279-y


https://www.news-medical.net/news/20230522/Gout-unveiled-as-surprising-culprit-in-neurodegenerative-diseases.aspx


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268604/#:~:text=Individuals%20with%20low%20uric%20acid,a%20risk%20factor%20for%20stroke.

Gout can also be a factor in brain cancer as fibroblasts and growth hormones are continuously compensating for the injuries in highly acidic intracranial fluid.

as well as circulating urate crystals can go into the lymphatic system and end up in the water lymphatic system of the eyes.  This can lead to darkened and murky vision during up flow of uric concentration.

Uncontrolled gout can cause cataracts, due to continuous eye damage from urate.   Also many report that allopurinol only post pones the processes of purine and fructose metabolism and is somewhat unaffective without solid dietary consistancy.  It takes months for this stuff to deposit and crystalize through out the body, it'll take months for it to deformalize completely, and have a stable uric blood concentration.  Usually people settle for the tip of the iceberg clearing up but never bother with whats still in the water.

Thus the increase in dose.

Heres the content on gout remedies. Theyre called xanthine oxidase inhibitors. Celery, onion are very potent, ginger and garlic also work well, dont over do it since theyre blood thinners. Info on lemon water and potassium citrate which needs to be properly measured out to avoid metabolic alkaloses or potassium overdose. I take maximum 1.4 grams a day with flare. Equivalent to one banana. A small slice of beet can keep blood vessel function working properly. Meat, sugar, high fat and high salt must be avoided to make a fast recovery. salt increases sodium urate which is what crystalizes. Takes a month if eating habits are managed long term for full recovery. Ncbi.gov can provide interactions with allopurinol and other meds if searched for. discernment and proof reading is essential and vital for safe navigation. have a good week. Reddit has a big gout community.


heres a few links on uric acid xanthine oxidase inhibitors in food that work with diet change.

Searches for following foods and xanthine oxidase inhibitors show

Onions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252007/


Garlic

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409881/


Ginger

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654013/


Lemon Water

https://www.medicalnewstoday.com/articles/lemon-juice-and-gout


Celery (toxic if consumed in large quantities long term due to mannitol content)

https://www.healthline.com/health/gout/can-different-parts-of-the-celery-plant-naturally-treat-gout#:~:text=Celery%20seed%20contains%20compounds%20that,anti%2Dinflammatory%20and%20antioxidant%20properties.


Transveratrol

https://www.researchgate.net/publication/363659529_Oxidized_Resveratrol_Metabolites_as_Potent_Antioxidants_and_Xanthine_Oxidase_Inhibitors


coffee or caffeine containing tea

https://pubmed.ncbi.nlm.nih.gov/26905267/